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The Federal Drug Enforcement Administration is now involved in the death investigation of Prince, and our law enforcement sources say drugs are the focal point of the criminal probe.

Our sources say the DEA and the Minnesota Attorney General are looking into the various prescriptions that were written for Prince, and the focus is opiates. Prince had a life-threatening Percocet addiction and authorities believe opiates will likely be either the sole or at least a significant factor in his death.

Our sources say the investigation is sweeping ... doctors and pharmacies involved in prescribing and filling meds for Prince are targeted, but possible enablers are also in the crosshairs.

Our sources now say the toxicology report may still be weeks away, although it was initially set to be released 2 weeks after the autopsy.

Mick Jagger doesn't give a rat's ass how many delegates Donald Trump's secured, he and the Rolling Stones are putting the kibosh on their music getting played at Trump rallies.

The Stones fired off a cease and desist letter to the campaign requesting they "cease all use immediately" ... according to a statement from the band's rep.

Trump used their hit "Start Me Up" as his intro music during several Indiana campaign stops this week -- and clearly word got back to the Stones' legal team. The Donald's also used "You Can't Always Get What You Want" in the past.

Alec Baldwin exploded in anger Tuesday, getting in a photographer's face and berating him for shooting Baldwin's wife.

Baldwin and Hilaria were in Bev Hills when he unleashed on the photog with ear-shattering volume, ordering him to "shut up."

It's unclear what preceded Baldwin's tirade, but he tells the photog in no uncertain terms his wife is out of bounds for the paparazzi ... interesting for sure, because Hilaria is a prolific Instagram user who chronicles her life on the app. She's also a correspondent for "Extra."

It's even more interesting ... Baldwin wrote an essay where he said he was moving from New York to California because he can't stand the paparazzi presence in the Big Apple. He wrote in New York Magazine, "L.A. is a place where you live behind a gate, you get in a car, your interaction with the public is minimal."

The incident occurred in a very public part of town ... Bedford Drive in Beverly Hills.

Prince's death is creating a unique issue for Minnesota lawmakers ... in the eyes of a prominent attorney with a reality TV show.

Rhonda Wills, one of the attorneys from "Sisters In Law" on WE tv, weighed in on the mad scramble to cash in on Prince's name and likeness ... and pointed out there's never been a situation like this in the Land of 10,000 Lakes.

Check out the clip ... she's strongly hinting it might be time for a change. Of course, Rhonda practices law in Texas, not Minnesota -- but 'Sisters' fans know ... she tends to get what she wants.

Janet Jackson's finally confirmed what's been pretty clear since she pulled out of her world tour -- she's knocked up.

Janet and her husband, Wissam Al Mana, are expecting their first child, according to ET. Janet, who will turn 50 on May 16, announced a month ago that she was indefinitely postponing the 'Unbreakable Tour' because she was "planning" her family.

She stopped short of saying she was pregnant at the time, but it was clear the "sudden change" had to be something that big for her to scrap the long-planned tour.

It's unclear how far along she is, but if you assume she's at least 3 months pregnant -- it'll probably be summer 2017 before Janet and her fans are ... Together Again.

Donnell Rawlings is laying down the law on who gets to drop "my n****" -- on the President or anyone else -- and says Larry Wilmore is in clear violation.

We caught up with the comedian outside Fred Segal, and he schooled us on why he thinks Wilmore crossed the line with the now infamous shout-out to Barack Obama.

Check out the video ... 'cause Donnell really went off when our camera guy asked if Obama is licensed to use the word.

#MicDrop

The family of the autistic teen 50 Cent bullied still wants the rapper to open up his wallet, but this time it's for a good cause and far less cash ... the family's attorney tells TMZ.

Attorney Matthew J. Hammer says Andrew Farrell and his family want 50 to cough up $10k for Autism Speaks, an autism advocacy group.

The donation is far less than the $1 million Andrew's stepdad was first eyeing.

We're told Andrew and his family received 50's signed, albeit short apology Tuesday via an email after news broke of Andrew's disabilities and were happy he said sorry.

As we reported, 50 got in Andrew's face at an airport accusing him of working while on drugs, when in fact he's autistic and is also afflicted by Asperger's.

50 has yet to answer back about the $10k donation.

Eminem's ex-wife, Kim Mathers, was trying to kill herself when she rolled her car into a ditch last October in an alleged drunk driving accident.

Kim called into the Detroit radio show "Mojo in the Morning" on channel 95.5 to come clean on the car accident. The case had been sealed, leading people to think she was getting preferential treatment from the court. Kim says the docs were sealed only because they had medical information related to her suicide attempt.

She admits she specifically found a road where no one else would get hurt, ingested pills and alcohol before she "hit the gas and aimed for a pole." Her Cadillac Escalade flipped but Kim ultimately survived the wreck.

Kim says she's currently getting help. Listen to the clip ... she also talks about how Eminem's helped her through the ordeal.

The addiction specialist who was at Prince's house the day he died brought a backpack containing a synthetic opiate ... and his criminal defense lawyer now insists he should not be prosecuted.

Prince's people called Dr. Howard Kornfeld the day before the singer died, saying they believed Prince was on the verge of dying from drugs. Prince was apparently on board to get help, but the doctor said it would be 2 days before he could get there.

Dr. Kornfeld sent his son, Andrew, who worked at their facility -- Recovery Without Walls. Andrew flew out early and was at Prince's home the day he died.

Andrew's lawyer, William Mauzy, just said Andrew did not supply Prince with any drugs, although he did have synthetic opiates in his backpack. The drug is called buprenorphine, a synthetic opiate for pain management and to wean people off actual opiates.

It was Andrew who called 911 after the staff found Prince unconscious in the elevator.

Sean Penn just scored a victory over Lee Daniels in his defamation lawsuit ... which they settled, but what's extraordinary is the apology letter Daniels had to write.

The "Empire" co-creator wrote, "I am so sorry that I have hurt you Sean, and I apologize and retract my reckless statements about you. How thoughtless of me. You are someone I consider a friend, a brilliant actor and true Hollywood legend and humanitarian."

Penn sued Daniels for $10 million over Lee comparing Terrence Howard's domestic violence history to Sean. He said, "[Terrence] ain't done nothing different than Marlon Brando or Sean Penn, and all of a sudden he's some f*****' demon."

The terms of the settlement are confidential ... although we know, at the very least, it included Lee's public apology/shaming -- and Lee making a donation to Penn's Haitian relief organization.

Lee's letter continues, "My most important role is as a father, and it is important to me that my children learn that it is wrong to reference gossip as fact, as I did here."

Dylan O'Brien -- the star of the 'Maze Runner' movies -- is still a beautiful specimen to be worshiped despite a broken face ... so says his co-star Dexter Darden.

We caught up with Darden, who gave us the lowdown on EXACTLY what happened during O'Brien's on-set accident. Production on "Maze Runner: The Death Cure" has been postponed while Dylan recovers.

Check out the vid ... Darden reveals how his pal is healing, and specifically ... how his face is doing. His fans will love this.

President Obama handpicked Rosa "Rosie" Rios to be the 43rd Treasurer of the United States ... so you'd think she'd have a quick answer when asked if BO's got a shot at being on U.S. currency.

We got the treasurer out at Craig's where she was Hollywood hobnobbing with legendary songwriter Diane Warren and 'Sopranos' star Lorraine Bracco.

Rios was appropriately proud when we asked her about Harriet Tubman getting on the $20 bill -- she spearheaded that movement, after all. Our follow-up about our current prez possibly making it onto a bill ... didn't go over that smoothly.

Watch, it seems like she's trying to blow off the question.

As for why she's hanging with celebs? Rosa's days in D.C. are likely just as numbered as her boss'.

Prince was supposed to meet with a doctor specializing in addiction treatment the day after he died ... to deal with a "grave medical condition."

Dr. Howard Kornfeld, a national authority on opioid addiction, could not clear his schedule on April 21st, so he sent his son, Andrew, to meet with the singer ... this according to the Star Tribune.

Dr. Kornfeld was supposed to come the following day, and his son -- who works with him at the Recovery Without Walls clinic -- was going to outline the course of treatment. Andrew is the person who called 911 to report Prince was lifeless in the elevator.

According to the report, Dr. Kornfeld was initially contacted by one of Prince's reps, who said the singer "was dealing with a grave medical emergency."

"A Nightmare on Elm Street" director Wes Craven is still raking in the dough after his death -- his Hollywood Hills home just sold for almost $250k above asking price.

The 3 bedroom, 3 bath pad was listed for $3.295 mil in April and was quickly sold for $3.535 mil ... with "Million Dollar Listing" stars Josh and Matt Altman as its listing agents.

The pad used to be owned by Steve McQueen -- and Wes, who died last summer, bought it in 1992. The genius behind horror classics like "Scream" actually had a pretty zen crib -- gardens, fountains, 2 koi ponds, saltwater pool and spa and amazing views.

Tupac's mother guarded his music and financial legacy in life, and TMZ has learned Afeni Shakur took extraordinary steps to do the same in death.

Afeni had set up a trust to control all of Tupac's music rights, and a rep for his estate tells us the paperwork is flawless. She also named the perfect executor, Tom Whalley -- former head of Warner Bros. Records -- to handle Tupac's valuable catalog.

We're told the trust is very specific about heirs, and the money is going to select charities and family. Afeni is survived by her sister, Gloria, and a daughter, Sekyiwa Shakur ... Tupac's half sister.

Her estranged husband, Gust Davis, is not mentioned in the trust -- so Tupac's money and music will be virtually untouchable in that divorce.

Interestingly, Tupac's mother was repped by attorney Howard King, who also worked with Prince years ago. He says Prince hated dealing with paperwork and rarely listened to advisors, but Afeni was the exact opposite -- which is why there shouldn't be any legal battles over Tupac's fortune.

Blac Chyna's going on the offensive to block tricky strippers and schemers from cashing in on her good name.

According to a trademark application filed last month ... BC's biz opportunities are exploding, so she's making sure she has the exclusive right to promote products with her name. Same goes for TV gigs, movie deals and party appearances.

Sources connected to Chyna tell us the concern is some other chick -- stripper or otherwise -- coming along and using the "Blac(k) Chyna" moniker.

The docs were filed just 2 weeks before she got engaged to Rob Kardashian, but we're told that's just coincidence -- it should've been done years ago.

Chyna's attorney, Walter Mosley, tells us the filing was prompted by her getting multiple film, TV and endorsement offers that have piqued her interest -- and it's his job to make sure her name, likeness and intellectual properties are protected.